Essential for progression beyond the immediate-early phase of infection.
Following activation, transcription of viral genes transitions from LAT to multiple lytic genes; these lead to enhanced replication and virus production.
HSV-1 tends to reside in the , while HSV-2 tends to reside in the , but these are tendencies only, not fixed behavior.
Chayavichitsilp P, Buckwalter JV, Krakowski AC, Friedlander SF April 2009.
At least four cases resulted in survival with severe neurologic impairment.
In another study, 73 subjects were randomized to receive 1 g daily or placebo for 60 days each in a two-way.